On their way to a cheer competition, the Middleton Cheer squad gets stranded at an old camp Ron has a long history with and face Gill, a high-school mutant who is determined to get his revenge on Ron.
After a mission to stop Dr. Drakken from using a top secret machine, Ron suddenly begins exhibiting profound intelligence in his writing. When he is kidnapped by Drakken and forced to construct a doomsday device however, Kim and subtly-changed Rufus join together to save him.
After flunking driver's ed Kim is visited by an automated car who's owner has been kidnapped by Drakken. After cheating by the car leads to a stellar pass, she must overcome her guilt to foil Drakken's improved army of Destructo-Bots and rescue Dr. Freeman.
Kim is hot on the trail of Drakken and Shego after they steal a weather machine in a bizarre plot to attack Canada. At the same time a disastrous job fair leaves her to deal with an obsessive janitor and Ron's mysterious spy master.
Kim takes a job at Bueno Nacho to pay for a fashionable jacket, convincing a reluctant Ron to keep her company by applying too. As Ron's career kicks off, making him assistant manager, the evil Dr. Drakken plots to destroy Wisconsin from inside a giant wheel of cheese, capturing Kim in the process. In order to save her, Ron must choose between his career or duty as sidekick.
Kim, on duty to guard a mysterious machine from Drakken becomes sick and is relegated to bed as others take up her duties.
In a mission to save a prominent scientist Kim and Ron are hit with a mysterious beam. Ron adapts well to his new honesty while Kim has to bite her tongue during a visit from her father's bosses.
Global Justice conducts an intensive study of Ron to determine whether he is the secret to Kim's success. Unfortunately a rival organization has plans of their own.